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PDF Search for Mac. PDF Search for Mac. PDF Search for Mac. 2 Cloner for Mac is an advanced Mac.Rho is a protein belonging to the Rho family.
Rho was first identified in 1980 as a component of a protein that bound to the ras oncogene. The ras oncogene is one of the oncogenes that is important in the development of human cancers, and it is known that the overexpression of ras oncogene results in cell transformation and in fact is the cause of at least half of all human cancer, and that the product of the ras oncogene itself directly participates in the transformation of cells. On the other hand, Rho was identified in 1980 and has been presumed to be a component of the ras oncogene due to a point of common DNA sequence (in 3' position of the ras gene) and highly conserved domain, which is present in the Rho protein of bacteria.
The Rho protein in organisms is known to be involved in cell growth, morphogenesis, and cell motility. In addition, the Rho protein is known to mediate signals for cell adhesion and migration.
In Japanese Patent Laid-open No. 68-95254, Rho is used for studies of alteration of gene characteristics due to somatic cell fusion, and its genomic DNA is isolated from porcine erythrocytes. In addition, there is a report that Rho in human blood platelets is released following platelet secretion, and that it is associated with pathologic conditions in the lung (see Biochimica et Biophysica Acta, 918 (1987), 454-461). However, there is no report on the association of Rho with tumors or cancer.
It has been known that most tumorous tissues contain increased numbers of tumor-associated macrophages and that such 0b46394aab
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